3D Hierarchical, Nanostructured Chitosan/PLA/HA Scaffolds Doped with TiO2

Published in Polymers, vol. 12(4), 792 (2020) · MDPI · Open access, CC BY
DOI: 10.3390/polym12040792

Summary

Bone is the second most frequently replaced tissue, with over four million surgical procedures a year, and tissue engineering offers an alternative to taking grafts from the patient. What it requires is a three-dimensional scaffold that resembles the body's own environment - and bone is highly organised and largely inorganic, so a simple polymer mesh will not do. This study builds hierarchical chitosan/PLA/hydroxyapatite scaffolds doped with TiO2, combining an organic matrix with the inorganic phases that bone tissue actually contains.

Authors & Affiliations

  • Julia Radwan-Prażłowska Corresponding
    Department of Physical Chemistry, Cracow University of Technology, Poland
  • Łukasz Janus
    Department of Physical Chemistry, Cracow University of Technology, Poland
  • Marek Piątkowski
    Department of Physical Chemistry, Cracow University of Technology, Poland
  • Dariusz Bogdał
    Department of Physical Chemistry, Cracow University of Technology, Poland
  • Dalibor Matýsek
    Faculty of Mining and Geology, Technical University of Ostrava, Czech Republic

Linari Electrospinning Systems

Linari NanoTech electrospinning system (RT Advanced)
The nanofibres were prepared on a Linari NanoTech system (Pisa, Italy) at two different potentials, 30 and 35 kV - field strengths that require the 60 kV generator of the RT Advanced.

Topics

Bone Tissue Engineering Hierarchical Scaffolds Hydroxyapatite Photocatalytic Doping

Materials

Chitosan Poly(lactic acid) Hydroxyapatite Titanium dioxide
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