Bio-Based Electrospun Fibers for Wound Healing

Summary

Skin is the first organ to be injured and is well equipped to repair itself, but deep or extensive wounds overwhelm that capacity and call for dressings and tissue substitutes. This review surveys biodegradable polymers of both synthetic and biological origin as materials for that purpose, focusing on the properties that matter clinically - biocompatibility, controlled degradation, and bioactivity that can be antimicrobial, immunomodulatory, proliferative or angiogenic. A central criterion is whether a polymer can be drawn into submicrometric fibres, since an electrospun mat reproduces the architecture of the extracellular matrix and creates the microenvironment in which healing proceeds. The article maps the available biobased options against these requirements and discusses where each is best suited.

Authors & Affiliations

• Bahareh Azimi Corresponding

  INSTM, Florence and Department of Civil and Industrial Engineering, University of Pisa, Italy
• Homa Maleki

  Department of Carpet, University of Birjand, Birjand, Iran
• Lorenzo Zavagna

  INSTM, Florence, Italy
• Jose Gustavo De la Ossa

  Doctoral School in Life Sciences, University of Siena, Italy
• Stefano Linari

  Linari Engineering S.r.l., 56121 Pisa, Italy
• Andrea Lazzeri

  INSTM, Florence and University of Pisa, Italy
• Serena Danti Corresponding

  INSTM, Florence and University of Pisa, Italy

Linari Electrospinning Systems

Topics

Materials