Summary
Poly(butylene succinate) (PBS) is a biodegradable aliphatic polyester attractive for tissue scaffolds and drug carriers, but on its own it is hydrophobic and offers limited control over release. This work uses coaxial electrospinning to combine PBS with poly(ethylene glycol) (PEG) in core–shell fibres, so that the two polymers occupy separate compartments of each filament. The authors show that whether PEG sits in the core or in the shell changes how strongly a loaded compound is retained, giving a practical handle on release kinetics, while PEG also improves the wettability of the otherwise hydrophobic matrix. The scaffolds were successfully loaded with hydrophobic drugs and assessed for biocompatibility, demonstrating that coaxial PBS/PEG fibres are promising biodegradable platforms for controlled, localised drug delivery.