Biodegradable Electrospun PLGA Nanofibers Encapsulating Trichinella Spiralis Antigens

Summary

The parasite Trichinella spiralis survives in its host by releasing products that dampen the immune response - and those same molecules, the ESL1 antigens, show promise for treating autoimmune diseases such as multiple sclerosis. The open question is timing: in a natural infection the antigens arrive gradually, and this study asks whether reproducing that controlled release improves the therapeutic effect. The antigens were encapsulated in biodegradable electrospun PLGA nanofibres, turning a parasite's evasion strategy into a delivery schedule.

Authors & Affiliations

• Ljiljana Sabljić

  Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Serbia
• Nataša Radulović

  Institute for Biological Research "Siniša Stanković", University of Belgrade, Serbia
• Jelena Đokić

  Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia
• Dusica B. Stojanovic

  Faculty of Technology and Metallurgy, University of Belgrade, Serbia
• Dragana Radojević

  Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia
• Sofija Glamočlija

  Institute for the Application of Nuclear Energy (INEP), University of Belgrade, Serbia
• Miroslav Dinić

  Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia

Linari Electrospinning Systems

Topics

Materials