Biomimetic polyurethane – Based fibrous scaffolds

Summary

Designing scaffolds that reproduce the biochemical, mechanical and structural functions of the extracellular matrix (ECM) is central to tissue engineering. This work develops biomimetic fibrous scaffolds based on polyurethane, chosen for the easy processability and tunable mechanical properties of synthetic elastomers, and combines it with the biochemical cues of natural materials so that the scaffold interacts positively with cells and supports tissue regeneration. The polyurethane is processed by electrospinning into fibrous mats that mimic the architecture of the native ECM, and the resulting scaffolds are characterised for their physicochemical and mechanical properties. The approach aims to merge the durability of synthetic polymers with the bioactivity needed for functional tissue-engineering substrates.

Authors & Affiliations

• Chiara Tonda-Turo

  Dept. of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
• Monica Boffito

  Dept. of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
• Claudio Cassino

  Dept. of Science and Technology, University of Piemonte Orientale, Alessandria, Italy
• Piergiorgio Gentile

  School of Mechanical and Systems Engineering, Newcastle University, Newcastle upon Tyne, UK
• Gianluca Ciardelli

  Dept. of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

Topics

Materials

Linari Electrospinning Systems