Development of a bioactive glass-polymer composite for wound healing applications

Published in Materials Science and Engineering: C, vol. 76, pp. 224–232 (2017) · Elsevier
DOI: 10.1016/j.msec.2017.03.037

Summary

Wound healing depends on both fighting infection and building new blood vessels, so a dressing that delivers the right ions locally can actively speed recovery. This study develops a composite wound-healing material combining electrospun poly(ε-caprolactone) (PCL) fibres with sol-gel bioactive glass nanoparticles doped with two functional metal ions: silver (Ag) for its antibacterial action and cobalt (Co) to promote angiogenesis by mimicking hypoxia. The PCL fibres were produced by electrospinning from an acetone solution and combined with the doped glass, and the resulting fibrous mats were characterised for morphology, ion release and biological behaviour. The work shows that a single electrospun bioactive-glass/polymer composite can carry both antibacterial and pro-angiogenic functions, giving properties well suited to advanced wound-dressing applications.

Authors & Affiliations

Topics

Wound Healing Bioactive Glass Composites Antibacterial Materials Angiogenesis

Materials

Poly(ε-caprolactone) (PCL) Bioactive Glass Silver (Ag) Cobalt (Co)

Linari Electrospinning Systems

Electrospinning machines by Linari Nanotech
Linari Nanotech designs and manufactures electrospinning systems for nanofiber research and production — including ion-releasing bioactive-glass/polymer composites for wound dressings.
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