Development of Gelatin-Coated Hydrogel Microspheres for Novel Bioink Design

Summary

Building vascularised tissue remains one of the hardest problems in regenerative medicine, since engineered constructs die without a blood supply. Positively charged microspheres help on two fronts at once - they encourage vascularisation and release bioactive compounds in a controlled way. This study produces gelatin-coated microspheres, cross-linked with either EDC or transglutaminase, as components of a new bioink, so the printed construct carries its own pro-angiogenic elements rather than relying on the host to supply them.

Authors & Affiliations

• Jacob Zieman

  BioMolecular Engineering Program, Physics and Chemistry Department, USA
• Molly Cohan

  BioMolecular Engineering Program, Physics and Chemistry Department, USA
• Yiyang Wang

  Mechanical Engineering Department, University of Wisconsin, USA
• Alejandra De La Sancha

  BioMolecular Engineering Program, Physics and Chemistry Department, USA
• Mahesh Kanungo

  BioMolecular Engineering Program, Physics and Chemistry Department, USA
• Rania Azzouz

  Department of Biology, Midwestern State University, USA

Linari Electrospinning Systems

Topics

Materials