Summary
This work presents a low-cost, effective route to biocompatible nanofibre mats made from natural, protein- and cellulose-based materials. Silk fibroin was blended with pure cellulose and, in a greener variant, with cellulose-rich parsley-powder agro-waste, using trifluoroacetic acid as a single common solvent that produced highly homogeneous solutions suitable for electrospinning. The resulting composite nanofibres were well-defined and defect-free, with diameters of roughly 65–100 nm. Their mechanical behaviour could be tuned by composition: adding pure cellulose to fibroin stiffened the mats, whereas adding the parsley waste made them more flexible. Cell tests confirmed excellent biocompatibility, with the mats promoting fibroblast proliferation — showing that even food agro-waste can be turned into functional biomedical nanomaterials.