Mesenchymal Stem Cells and Myoblast Differentiation for 3D Skeletal Muscle Tissue Engineering

Summary

When trauma or tumour surgery removes a large volume of muscle, the loss exceeds what skeletal muscle can regenerate on its own. Tissue engineering aims to rebuild it by combining cell sources - myoblasts and mesenchymal stem cells - within a three-dimensional matrix. This study examines how those cells behave on electrospun scaffolds under stimulation with the growth factors HGF and IGF-1, asking whether growth factor signalling can push mesenchymal stem cells towards a myogenic fate in a 3D fibrous environment.

Authors & Affiliations

• Roman Witt

  Department of Plastic and Hand Surgery, University Hospital Erlangen, Germany
• Annika Weigand

  Department of Plastic and Hand Surgery, University Hospital Erlangen, Germany
• Anja M. Boos

  Department of Plastic and Hand Surgery, University Hospital Erlangen, Germany
• Aijia Cai

  Department of Plastic and Hand Surgery, University Hospital Erlangen, Germany
• Dirk Dippold

  Institute of Biomaterials, University of Erlangen-Nuremberg, Germany
• Aldo R. Boccaccini

  Institute of Biomaterials, University of Erlangen-Nuremberg, Germany
• Dirk W. Schubert

  Institute of Polymer Materials, University of Erlangen-Nuremberg, Germany

Linari Electrospinning Systems

Topics

Materials