Design of Mechanically Resistant and Biodegradable Multichannel Platforms for Peripheral Nerve Injuries

Summary

Peripheral nerve injury is among the most disabling conditions to treat, and full recovery remains rare despite decades of effort. This study develops flexible, mechanically resistant multichannel platforms intended to act as both support and guide for neural cells during regeneration, built from poly(lactic-co-glycolic acid). The multichannel geometry matters: it reproduces the parallel architecture along which axons must regrow, while the mechanical resistance ensures the structure survives implantation and movement without collapsing - the two requirements that most nerve conduits fail to satisfy simultaneously.

Authors & Affiliations

• Caterina Valentino

  Department of Drug Sciences, University of Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Giulia Zucca

  Department of Drug Sciences, University of Pavia, Italy
• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Giorgio Marrubini

  Department of Drug Sciences, University of Pavia, Italy
• Cinzia Boselli

  Department of Drug Sciences, University of Pavia, Italy
• Antonia Icaro Cornaglia

  Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy
• Giuseppina Sandri Corresponding

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials