Multimaterial and Multiscale Scaffold for Engineering the Enthesis Organ

Summary

Tendon and ligament injuries frequently fail to recover fully, and when surgical repair fails it usually fails at the enthesis - the point where tendon inserts into bone. That region is highly anisotropic and graded, mixing soft tissue with mineral, which is precisely what makes it hard to reproduce. This study builds a multimaterial, multiscale scaffold that combines electrospinning with other fabrication techniques, so that the gradient in composition and structure is engineered rather than approximated by a single uniform material.

Authors & Affiliations

• Simone Micalizzi

  Research Centre "E. Piaggio" and Department of Information Engineering, University of Pisa, Italy
• Letizia Russo

  Department of Pharmacy, University of Pisa, Italy
• Chiara Giacomelli

  Department of Pharmacy, University of Pisa, Italy
• Francesca Montemurro

  Research Centre "E. Piaggio", University of Pisa, Italy
• Carmelo de Maria Corresponding

  Research Centre "E. Piaggio" and Department of Information Engineering, University of Pisa, Italy
• Matteo Nencioni

  Department of Pharmacy, University of Pisa, Italy

Linari Electrospinning Systems

Topics

Materials