Potential of Electrospun Poly(3-hydroxybutyrate)/Collagen Blends for Tissue Engineering

Published in Journal of Healthcare Engineering, 6573947 (2018) · Hindawi · Open access, CC BY
DOI: 10.1155/2018/6573947

Summary

Poly(3-hydroxybutyrate) is a bacterially produced polyester, biodegradable but stiff; type I collagen is the protein cells actually recognise. Blending them at ratios of 100/0, 70/30 and 50/50 and electrospinning the result gives nonwoven mats whose morphological, thermal, mechanical and degradation properties all shift with the ratio. The blend ratio therefore becomes a single dial controlling several properties at once - useful when a scaffold must match a specific tissue.

Authors & Affiliations

  • Luca Salvatore
    Department of Engineering for Innovation, University of Salento, Lecce, Italy
  • Vito E. Carofiglio
    Distretto Tecnologico High Tech DHITECH Scarl, Lecce, Italy
  • Paolo Stufano
    EggPlant Srl, Polignano a Mare, Italy
  • Valentina Bonfrate
    Department of Engineering for Innovation, University of Salento, Lecce, Italy
  • Emanuela Calò
    Department of Engineering for Innovation, University of Salento, Lecce, Italy

Linari Electrospinning Systems

Linari Engineering electrospinning system
The mats were produced on a Linari Engineering system (Italy) with a 15 ml glass syringe connected to a stainless steel blunt needle - glass being the usual choice when the solvent would attack a plastic barrel. See our range of systems.

Topics

Tissue Engineering Blend Ratio Control Biodegradable Polyesters Industrial Collaboration

Materials

Poly(3-hydroxybutyrate) Type I collagen
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