Release Profiles of Carvacrol or Chlorhexidine from PLA/Graphene Nanoplatelet Membranes

Published in Molecules, vol. 28(4), 1967 (2023) · MDPI · Open access, CC BY
DOI: 10.3390/molecules28041967

Summary

Nanofibrous membranes are the core of most controlled-release devices, and electrospinning is the usual way to make them - but it is slow, costly and hard to scale. Solution blow spinning has been proposed as a faster alternative. This study compares the two directly, producing PLA membranes with graphene nanoplatelets loaded with either carvacrol or chlorhexidine and measuring how each production route affects the release profile. Comparing techniques on identical formulations is the only way to know what is gained or lost in switching.

Authors & Affiliations

  • Roberto Scaffaro Corresponding
    Department of Engineering, University of Palermo, Italy
  • Luca Settanni
    Department of Agricultural, Food and Forestry Sciences, University of Palermo, Italy
  • Emmanuel Fortunato Gulino
    Department of Engineering, University of Palermo, Italy

Linari Electrospinning Systems

Linari Engineering - Biomedical Division system
The electrospun membranes were produced on a system from Linari Engineering - Biomedical Division (Pisa, Italy), with the process conditions held constant across all samples so that the comparison with blow spinning would be meaningful. See our range of systems, which also covers blow spinning.

Topics

Controlled Release Solution Blow Spinning Process Comparison Antimicrobial Membranes

Materials

Poly(lactic acid) Graphene nanoplatelets Carvacrol Chlorhexidine
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