Summary
A three-layered scaffold is built by emulsion and sequential electrospinning, with a PLGA fibre layer sandwiched between two polycaprolactone layers - a structure designed so the outer layers slow the escape of a drug held in the middle. The distinctive contribution is the pairing of experiment with a computational model: measured release rates are compared against simulation, so the layered architecture can be tuned by calculation rather than by repeated trial, a considerable saving when each variant takes days to test.
Authors & Affiliations
Linari Electrospinning Systems
Linari Engineering system with syringe pump
The scaffolds were prepared on a Linari Engineering system with a syringe pump, spinning each layer in sequence onto the previous one. Building a multilayer structure in successive runs requires the process to be reproducible from one run to the next - see our range of systems.