Biomimetic Design of Bioartificial Scaffolds for In Vitro Modelling of Human Cardiac Fibrosis

Summary

In vitro models of diseased cardiac tissue are valuable for testing therapies before animal or clinical studies, but existing ones rarely reproduce the specific features that matter - the size of the fibrotic region and the stage it has reached. This work engineers 2D and 3D models of early-stage post-infarct fibrosis on bioartificial scaffolds, a stage characterised by tissue that is not yet aligned. Controlling thickness and width of the fibrotic region turns the model into a platform where a therapy can be tested against a defined pathological state rather than a generic one.

Authors & Affiliations

• Mattia Spedicati

  Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
• Gerardina Ruocco

  Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
• Alice Zoso

  Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
• Leonardo Mortati

  Istituto Nazionale di Ricerca Metrologica (INRIM), Turin, Italy
• Andrea Lapini

  Istituto Nazionale di Ricerca Metrologica (INRIM), Turin, Italy
• Andrea Delledonne

  Department of Chemistry, Life Science and Environmental Sustainability, University of Parma, Italy
• Carla Divieto

  Istituto Nazionale di Ricerca Metrologica (INRIM), Turin, Italy
• Valeria Romano

  Department of Public Health, University of Naples "Federico II", Italy

Linari Electrospinning Systems

Topics

Materials