Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons

Summary

When a chronically injured tendon is repaired surgically, the scar tissue that forms has different mechanical properties from healthy tendon, leaving the repair prone to re-injury or rupture. This study addresses that weak point with a scaffold of thermoplastic polyurethane doped with cerium oxide and chondroitin sulfate: the polyurethane supplies elasticity comparable to the native tissue, cerium oxide contributes antioxidant activity against the inflammation that accompanies tendon disorders, and chondroitin sulfate provides a biological cue familiar to the cells that must repopulate the bridge.

Authors & Affiliations

• Eleonora Bianchi

  Department of Drug Sciences, University of Pavia, Italy
• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Elena Del Favero

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Caterina Ricci

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Cinzia Boselli

  Department of Drug Sciences, University of Pavia, Italy
• Antonia Icaro Cornaglia

  Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Italy
• César Viseras

  Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain

Linari Electrospinning Systems

Topics

Materials