Chitosan/Glycosaminoglycan Scaffolds: Silver Nanoparticles to Control Microbial Infections

Summary

Around 300 million people worldwide live with chronic wounds and another 100 million with traumatic ones, and infection is what most often stalls the healing process. This study develops electrospun scaffolds loaded with silver nanoparticles to accelerate cutaneous healing while preventing infection. The nanoparticles were added directly to polymer blends of chitosan and glycosaminoglycans, so the antibacterial agent is distributed through the fibre rather than applied afterwards - the point being to control silver release rather than simply maximise it.

Authors & Affiliations

• Giuseppina Sandri Corresponding

  Department of Drug Sciences, University of Pavia, Italy
• Dalila Miele

  Department of Drug Sciences, University of Pavia, Italy
• Angela Faccendini

  Department of Drug Sciences, University of Pavia, Italy
• Maria Cristina Bonferoni

  Department of Drug Sciences, University of Pavia, Italy
• Silvia Rossi

  Department of Drug Sciences, University of Pavia, Italy
• Pietro Grisoli

  Department of Drug Sciences, University of Pavia, Italy
• Angelo Taglietti

  Department of Chemistry, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials