Coated Electrospun Alginate-Containing Fibers as Novel Delivery Systems for Regenerative Purposes

Summary

Alginate is attractive for tissue repair but will not electrospin on its own; it needs a spinnable partner. This study compares two candidates - dextran and poly(ethylene oxide) - as process adjuvants for biodegradable alginate-containing fibrous membranes intended to serve simultaneously as drug delivery systems and as guidance for cell growth. The membranes were then coated, adding a second layer of control over how quickly the drug leaves the fibre.

Authors & Affiliations

• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Silvia Rossi Corresponding

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri

  Department of Drug Sciences, University of Pavia, Italy
• Maria Cristina Bonferoni

  Department of Drug Sciences, University of Pavia, Italy
• Gloria Milanesi

  Department of Drug Sciences, University of Pavia, Italy
• Giovanna Bruni

  Department of Chemistry, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials