Collagen/PCL Nanofibers Electrospun in Green Solvent by DOE Assisted Process

Published in Materials, vol. 13(21), 4698 (2020) · MDPI · Open access, CC BY
DOI: 10.3390/ma13214698

Summary

Collagen is widely used in dressings and scaffolds for its biocompatibility and low antigenicity, and blending it with polycaprolactone improves its mechanical stability. The difficulty has been the solvent: collagen/PCL blends were traditionally spun from hexafluoroisopropanol or trifluoroethanol, both aggressive. This study replaces them with a green solvent and uses design of experiments to navigate the process window systematically rather than by trial and error - a methodical approach to a combination that is otherwise awkward to spin.

Authors & Affiliations

  • Dalila Miele
    Department of Drug Sciences, University of Pavia, Italy
  • Laura Catenacci
    Department of Drug Sciences, University of Pavia, Italy
  • Silvia Rossi
    Department of Drug Sciences, University of Pavia, Italy
  • Giuseppina Sandri
    Department of Drug Sciences, University of Pavia, Italy
  • Milena Sorrenti
    Department of Drug Sciences, University of Pavia, Italy
  • Alberta Terzi
    Institute of Crystallography, CNR-IC, Bari, Italy
  • Cinzia Giannini
    Institute of Crystallography, CNR-IC, Bari, Italy

Linari Electrospinning Systems

Linari electrospinning system
The fibres were produced on a Linari Engineering system (Pisa, Italy) with a 10 ml glass syringe and a stainless steel needle of 0.8 mm diameter and 15 mm length - the needle supplied as standard with our Starter Kit, control unit HVG-CONT-LCD.

Topics

Green Solvents Design of Experiments Process Optimization Collagen Scaffolds

Materials

Collagen Polycaprolactone
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