A Composite Nanosystem for the Local Treatment of Glioblastoma Multiforme

Summary

Glioblastoma multiforme is among the most aggressive brain tumours and currently has no cure, which makes local delivery at the resection site an attractive alternative to systemic treatment. This study proposes a composite nanosystem in which chitosan-coated solid lipid nanoparticles are embedded within nanofibres containing O-carboxymethyl chitosan. Coacervation was used to produce the nanoparticles without solvents, and the fibres then act as the retaining matrix - giving a two-level structure where the fibre holds position at the site while the nanoparticle carries the lipophilic anti-proliferative drug.

Authors & Affiliations

• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Caterina Valentino

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri

  Department of Drug Sciences, University of Pavia, Italy
• Roberta Listro

  Department of Drug Sciences, University of Pavia, Italy
• Francesca Fagiani

  Department of Drug Sciences, University of Pavia, Italy
• Simona Collina

  Department of Drug Sciences, University of Pavia, Italy
• Cristina Lanni

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials