Summary
This study builds core-sheath nanofibres with chitosan forming the sheath and a cyclodextrin polymer the core, loaded with the antibacterial triclosan. Cyclodextrins host guest molecules inside their cavities, so placing them in the core creates a reservoir that holds the drug and releases it gradually. For comparison, monolithic fibres of the same blended components were also made - the contrast between the two showing how much the coaxial architecture itself contributes to controlling release.
Authors & Affiliations
Linari Electrospinning Systems
Linari NanoTech coaxial needle (21 G inner / 15 G outer)
The core-sheath fibres were produced with a Linari NanoTech coaxial needle (Pisa, Italy) of 21 gauge inner and 15 gauge outer diameter, with the two solutions loaded into separate syringes - the standard arrangement described on our coaxial needles page.