Summary
pH-sensitive polymers such as the Eudragit L100 and S100 families are widely used to make fibres that hold their drug until they reach the intended part of the gut. The assumption is that an insoluble polymer at low pH will retain its cargo - but this study shows that is not always true. By examining how the molecular properties of the active ingredient govern its release from electrospun Eudragit fibres, the work identifies why some drugs escape prematurely, which matters for anyone designing targeted oral delivery.
Authors & Affiliations
Linari Electrospinning Systems
Linari coaxial spinneret with two syringe pumps
The fibres were produced on a Linari Engineering system (Pisa, Italy) using two separate syringe pumps feeding a coaxial spinneret of defined internal and external diameters - the arrangement required for core-shell drug delivery fibres.