Electrospun Gelatin-Chondroitin Sulfate Scaffolds Loaded with Platelet Lysate

Summary

Corrective surgery for critical congenital heart defects leaves the heart needing help to recover, and this study develops patches intended to be implanted for exactly that purpose. Nanofibrous scaffolds of gelatin and chondroitin sulfate were produced by electrospinning and then loaded with platelet lysate as a source of growth factors, so the patch does not merely provide a physical support but actively supplies the signals that drive repair. Both components are already familiar in clinical use, which eases the path towards application.

Authors & Affiliations

• Francesca Saporito

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri Corresponding

  Department of Drug Sciences, University of Pavia, Italy
• Maria Cristina Bonferoni

  Department of Drug Sciences, University of Pavia, Italy
• Silvia Rossi

  Department of Drug Sciences, University of Pavia, Italy
• Lorenzo Malavasi

  Department of Chemistry, Physical Chemistry Section, University of Pavia, Italy
• Claudia Del Fante

  Immunohaematology and Transfusion Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials