Electrospun PCL Fiber Mats Incorporating B and Co Co-Doped Bioactive Glass Nanoparticles

Summary

New tissue only survives if blood vessels reach it, which makes promoting vascularisation a central problem in tissue engineering. Biologically active ions can stimulate angiogenesis, but combinations acting on more than one target at a time have rarely been tested. This study embeds bioactive glass nanoparticles co-doped with boron and cobalt into electrospun polycaprolactone fibre mats, so that two pro-angiogenic ions are released together from a single scaffold - a multi-target approach in place of the usual single-ion strategies.

Authors & Affiliations

• Si Chen

  Centre for Functional and Surface Functionalized Glass, Alexander Dubček University of Trenčín, Slovakia
• Dagmar Galusková

  Centre for Functional and Surface Functionalized Glass, Trenčín, Slovakia
• Hana Kaňková

  Centre for Functional and Surface Functionalized Glass, Trenčín, Slovakia
• Kai Zheng

  Institute of Biomaterials, University of Erlangen-Nuremberg, Germany
• Martin Michálek

  Centre for Functional and Surface Functionalized Glass, Trenčín, Slovakia
• Liliana Liverani

  Institute of Biomaterials, University of Erlangen-Nuremberg, Germany
• Dušan Galusek

  Centre for Functional and Surface Functionalized Glass, Trenčín, Slovakia

Linari Electrospinning Systems

Topics

Materials