Electrospun Scaffolds Based on Poly(butyl cyanoacrylate) for Tendon Tissue Engineering

Summary

Tendon injuries are slow to treat and frequently disappointing in outcome, because the repaired tissue is weaker than the original and joint mechanics change after surgery. This study designs nanofibrous scaffolds based on poly(butyl cyanoacrylate) as an alternative approach, exploiting a polymer already familiar in surgical adhesives but not previously exploited in this fibrous form. The scaffolds are characterised for the properties that matter in tendon repair - mechanical resistance, cell compatibility and the ability to guide regeneration along the direction of load.

Authors & Affiliations

• Eleonora Bianchi

  Department of Drug Sciences, University of Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Elena Del Favero

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Caterina Ricci

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Pietro Grisoli

  Department of Drug Sciences, University of Pavia, Italy
• Anita Ferraretto

  IRCCS Galeazzi Orthopaedic Institute, Milan, Italy
• Silvia Rossi Corresponding

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials