Gellan-Based Composite System for the Treatment of Nervous Tissue Injuries

Summary

Injuries to the nervous system affect more than a billion people and weigh heavily on quality of life, yet delivering a neuroprotective drug precisely where the damage is remains difficult. This study designs a gellan gum-based composite for local delivery of RC-33, an agonist of the sigma-1 receptor with neuroprotective activity. The system combines cross-linked electrospun nanofibres with a second component, so that the fibres provide structure and residence at the injury site while the drug is released locally instead of systemically.

Authors & Affiliations

• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Caterina Valentino

  Department of Drug Sciences, University of Pavia, Italy
• Valeria Cavalloro

  Department of Drug Sciences, University of Pavia, Italy
• Laura Catenacci

  Department of Drug Sciences, University of Pavia, Italy
• Milena Sorrenti

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri

  Department of Drug Sciences, University of Pavia, Italy
• Maria Cristina Bonferoni

  Department of Drug Sciences, University of Pavia, Italy
• Chiara Bozzi

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials