In-vitro Characterization of a Hernia Mesh Featuring a Nanostructured Coating

Published in Frontiers in Bioengineering and Biotechnology, vol. 8, 589223 (2020) · Frontiers Media · Open access, CC BY
DOI: 10.3389/fbioe.2020.589223

Summary

Polypropylene surgical mesh is the standard of care in abdominal hernia repair, reinforcing weakened tissue far more reliably than suture alone. Its weakness is at the interface: the mesh integrates poorly with surrounding tissue, which can lead to complications. This study characterises in vitro a hernia mesh carrying an electrospun nanostructured coating, so that the implant keeps the mechanical strength of polypropylene while presenting a fibrous surface that cells recognise - a way of improving integration without changing the device itself.

Authors & Affiliations

  • Giulia Giuntoli
    Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy
  • Giuliana Muzio
    Department of Clinical and Biological Sciences, University of Turin, Italy
  • Chiara Actis
    Department of Clinical and Biological Sciences, University of Turin, Italy
  • Andrea Ganora
    Dipromed Medical Devices S.r.l., Turin, Italy
  • Silvia Calzone
    Dipromed Medical Devices S.r.l., Turin, Italy
  • Marco Bruno
    Dipromed Medical Devices S.r.l., Turin, Italy
  • Gianluca Ciardelli
    Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Italy

Linari Electrospinning Systems

Linari Engineering electrospinning equipment
The nanostructured coating was applied using Linari Engineering S.r.l. electrospinning equipment, with the solutions loaded into 5 ml Luer-lock glass syringes fitted with 21-gauge needles - the standard configuration supplied with our complete stations. Coating an existing medical device is a typical industrial use of electrospinning.

Topics

Hernia Meshes Medical Device Coating Tissue Integration Industrial Collaboration

Materials

Polypropylene mesh Electrospun nanofiber coating
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