Nanoclay-Doped Electrospun Nanofibers for Tissue Engineering

Summary

Clay minerals have come to be seen as active excipients rather than inert fillers, capable of promoting cell adhesion, proliferation and differentiation - and their effect is amplified when they are dispersed within a three-dimensional polymer nanostructure rather than simply mixed in. This study examines scaffolds doped with hectorite and with montmorillonite as treatments for deep and chronic skin lesions, comparing the two nanoclays for their influence on scaffold structure and on the interaction with cells, so that the choice of clay becomes a design parameter rather than an incidental one.

Authors & Affiliations

• Dalila Miele

  Department of Drug Sciences, University of Pavia, Italy
• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• César Viseras

  Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain
• Francesca Natali

  Institut Laue-Langevin, Grenoble, France
• Elena Del Favero

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Silvia Rossi

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri Corresponding

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials