Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug

Summary

Infection remains one of the hardest obstacles in non-healing wounds, and antibiotic resistance has made straightforward drug loading less effective. This study compares two ways of delivering norfloxacin from polysaccharide scaffolds - as free drug, or bound to montmorillonite as a nanocomposite - across three scaffold types based on chitosan, chitosan/chondroitin sulfate and chitosan/hyaluronic acid. Putting the two delivery strategies side by side in identical scaffolds isolates the contribution of the clay carrier to release behaviour and antibacterial effect.

Authors & Affiliations

• Angela Faccendini

  Department of Drug Sciences, University of Pavia, Italy
• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Dalila Miele

  Department of Drug Sciences, University of Pavia, Italy
• Silvia Rossi

  Department of Drug Sciences, University of Pavia, Italy
• Maria Cristina Bonferoni

  Department of Drug Sciences, University of Pavia, Italy
• Carola Aguzzi

  Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain
• Pietro Grisoli

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials