Protein-Based Electrospun Nanofibers Doped with Selenium Nanoparticles for Wound Repair

Summary

Scaffolds that imitate the extracellular matrix are central to regenerative medicine, and this study asks how the choice of protein and the addition of selenium nanoparticles affect their performance. Selenium nanoparticles were synthesised by a redox reaction and stabilised with pullulan, then blended with either gelatin or gliadin and electrospun into nanofibrous scaffolds. Comparing the two proteins under identical doping conditions isolates the contribution of each to scaffold morphology, stability and regenerative potential - relevant to chronic wounds, where antioxidant activity and a matrix-like architecture are both needed.

Authors & Affiliations

• Marco Ruggeri

  Department of Drug Sciences, University of Pavia, Italy
• Sara Marsani

  Department of Drug Sciences, University of Pavia, Italy
• Alessia Ungolo

  Department of Drug Sciences, University of Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Eleonora Bianchi

  Department of Drug Sciences, University of Pavia, Italy
• César Viseras

  Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain
• Silvia Rossi

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri Corresponding

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials