Smart Device for Biologically Enhanced Functional Regeneration of Osteo-Tendon Interface

Published in Pharmaceutics, vol. 13(12), 1996 (2021) · MDPI · Open access, CC BY
DOI: 10.3390/pharmaceutics13121996

Summary

A lacerated tendon heals by forming scar tissue that never regains the functionality of the original, and chronic non-healing injuries usually end in surgery. This study develops an electrospun hybrid tubular scaffold intended to accompany the surgical procedure and improve healing at the injured site, specifically at the osteo-tendon interface where soft and hard tissue meet. The tubular geometry and the hybrid composition are chosen to bridge that transition biologically as well as mechanically.

Authors & Affiliations

  • Angela Faccendini
    Department of Drug Sciences, University of Pavia, Italy
  • Eleonora Bianchi
    Department of Drug Sciences, University of Pavia, Italy
  • Marco Ruggeri
    Department of Drug Sciences, University of Pavia, Italy
  • Barbara Vigani
    Department of Drug Sciences, University of Pavia, Italy
  • Cesare Perotti
    Immunohaematology and Transfusion Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Francesca C. Pavesi
    Orthopaedics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Laura Caliogna
    Orthopaedics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
  • Francesca Natali
    Institut Laue-Langevin, Grenoble, France

Linari Electrospinning Systems

Electrospinning Starter Kit (40 kV)
The tubular scaffolds were produced on a Linari Engineering system (Pisa, Italy) with a 40 kV high voltage power supply, a 10 ml syringe and a stainless steel needle - the Starter Kit configuration (STKIT-40), control unit HVG-CONT-LCD.

Topics

Osteo-Tendon Interface Tubular Scaffolds Functional Regeneration Surgical Support

Materials

Hybrid biopolymer scaffolds
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