Spermidine Crosslinked Gellan Gum-Based Hydrogel Nanofibers for Nervous Tissue Injuries

Summary

This study builds a neural scaffold intended for the site of a nervous tissue injury, combining neuroprotection with a structure that supports regeneration. Nanofibres were electrospun from gellan gum, spermidine and gelatin: spermidine was chosen for two reasons at once, its neuroprotective activity and its cationic nature, which makes it an effective cross-linking agent for gellan gum, while gelatin was added to improve bioactivity. The result is a hydrogel nanofibre in which the cross-linker is itself therapeutic rather than a chemical to be tolerated.

Authors & Affiliations

• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Caterina Valentino

  Department of Drug Sciences, University of Pavia, Italy
• Giuseppina Sandri

  Department of Drug Sciences, University of Pavia, Italy
• Carla M. Caramella

  Department of Drug Sciences, University of Pavia, Italy
• Franca Ferrari

  Department of Drug Sciences, University of Pavia, Italy
• Silvia Rossi Corresponding

  Department of Drug Sciences, University of Pavia, Italy

Linari Electrospinning Systems

Topics

Materials