Surface Engineering of Electrospun PLA Fibers via Chitosan/Hyaluronic Acid Polyelectrolyte Complexes

Summary

This study controls the release of rosmarinic acid from electrospun poly(L-lactide) fibres by engineering their surface with chitosan/hyaluronic acid polyelectrolyte complexes. The active compound was placed selectively in the fibre bulk, in the coating, or in both, so that its spatial distribution could be varied independently of the total load. Applied by sequential dip coating, the polyelectrolyte layer behaves as a diffusion-regulating barrier with a dual character: it slows release when the drug sits inside the fibre, and accelerates the initial burst when it acts as a surface reservoir. The result is a hierarchical design strategy in which release kinetics are tuned by where the molecule is placed rather than by reformulating the polymer.

Authors & Affiliations

• Selin Kyuchyuk

  Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Dilyana Paneva

  Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Milena Ignatova Corresponding

  Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Nevena Manolova

  Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Iliya Rashkov

  Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Daniela Karashanova

  Institute of Optical Materials and Technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Milena Mourdjeva

  Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria
• Nadya Markova

  Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

Linari Electrospinning Systems

Topics

Materials