Topographical and Compositional Gradient Tubular Scaffold for Bone to Tendon Interface Regeneration

Summary

The enthesis - where tendon meets bone - is a graded tissue in which fibrocartilage blends into mineral, and that gradient is precisely why it tears: the stiffness mismatch between soft tissue and hard bone concentrates stress, and surgical reconstructions frequently fail in the same place. This study develops a tubular scaffold based on pullulan and chitosan with a deliberate topographical and compositional gradient, so that the implant reproduces the transition instead of forcing an abrupt junction between materials of very different stiffness.

Authors & Affiliations

• Eleonora Bianchi

  Department of Drug Sciences, University of Pavia, Italy
• Angela Faccendini

  Department of Drug Sciences, University of Pavia, Italy
• Elena Del Favero

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Caterina Ricci

  Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
• Laura Caliogna

  Orthopaedics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
• Barbara Vigani

  Department of Drug Sciences, University of Pavia, Italy
• Francesca C. Pavesi

  Orthopaedics, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
• Cesare Perotti

  Immunohaematology and Transfusion Service, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Linari Electrospinning Systems

Topics

Materials