Summary
Coaxial fibres are attractive for guided tissue regeneration because a bioactive compound can be protected inside the core and released over a long period rather than dumped at once. This study builds antibacterial coaxial membranes of poly-ε-caprolactone loaded with rifampicin, and asks a specific question: does it matter whether the drug sits in the core or in the shell? Both configurations were compared against non-coaxial matrices, showing how the position of the drug within the fibre - not just its quantity - governs the release profile and the duration of antibacterial activity.
Authors & Affiliations
Linari Electrospinning Systems
Coaxial electrospinning needles by Linari NanoTech
The coaxial membranes were produced using equipment from Linari NanoTech (Pisa, Italy). Feeding the drug through the core while spinning the shell from a separate solution is exactly what our coaxial needles are designed for.