A Straightforward Method to Produce Multi-Nanodrug Delivery Systems for Transdermal/Tympanic Patches

Summary

Transdermal patches have never quite fulfilled their promise as an alternative to injections and oral dosing. This study offers a proof of concept for a dual drug-loaded patch produced with a single piece of equipment: the electrospinning apparatus is used first to spin fibres and then, by tuning the process, to generate nanoparticles that decorate them. Fibre meshes of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) loaded with dexamethasone were combined with rhodamine-loaded PLGA nanoparticles acting as a second model drug. The resulting nanoparticle/fibre systems are intended for local release through the skin and through the tympanic membrane, and were assessed on human dermal fibroblasts.

Authors & Affiliations

• Bahareh Azimi Corresponding

  Department of Civil and Industrial Engineering, University of Pisa, Italy
• Claudio Ricci

  Department of Civil and Industrial Engineering, University of Pisa, Italy
• Teresa Macchi

  Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy
• Cemre Günday

  MyBiotech GmbH, Überherrn, Germany
• Serena Munafò

  Department of Civil and Industrial Engineering, University of Pisa, Italy
• Homa Maleki

  Faculty of Arts, University of Birjand, Iran
• Federico Pratesi

  Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Italy
• Veronika Tempesti

  INSTM, Florence, Italy
• Caterina Cristallini

  INSTM, Florence, Italy
• Luca Bruschini

  Department of Surgical, Medical, Molecular Pathology and Emergency Medicine, University of Pisa, Italy
• Andrea Lazzeri

  Department of Civil and Industrial Engineering, University of Pisa, Italy
• Serena Danti Corresponding

  Department of Civil and Industrial Engineering, University of Pisa, Italy
• Nazende Günday-Türeli

  MyBiotech GmbH, Überherrn, Germany

Linari Electrospinning Systems

Topics

Materials